2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100805S1
    D-Glutamic acid-13C5,15N 1202063-56-6
    D-Glutamic acid-13C5,15N ((R)-Glutamic acid-13C5,15N) is 13C and 15N labeled D-Glutamic acid. D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
    D-Glutamic acid-13C5,15N
  • HY-100805S2
    D-Glutamic acid-13C5 1202063-54-4
    D-Glutamic acid-13C5 ((R)-Glutamic acid-13C5) is 13C labeled D-Glutamic acid. D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
    D-Glutamic acid-13C5
  • HY-100811AR
    7-Chlorokynurenic acid sodium salt (Standard) 1263094-00-3
    7-Chlorokynurenic acid (sodium salt) (Standard) is the analytical standard of 7-Chlorokynurenic acid (sodium salt). This product is intended for research and analytical applications. 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.
    7-Chlorokynurenic acid sodium salt (Standard)
  • HY-100815BR
    (RS)-AMPA (Standard) 77521-29-0
    (RS)-AMPA (Standard) is the analytical standard of (RS)-AMPA. This product is intended for research and analytical applications. (RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors.
    (RS)-AMPA (Standard)
  • HY-101139AR
    Xanthine amine congener hydrochloride (Standard) 1783977-95-6
    Xanthine amine congener (hydrochloride) (Standard) is the analytical standard of Xanthine amine congener (hydrochloride). This product is intended for research and analytical applications. Xanthine amine congener (XAC) hydrochloride is a non-selective adenosine receptor antagonist. Xanthine amine congener hydrochloride induces convulsions in mice.
    Xanthine amine congener hydrochloride (Standard)
  • HY-101321AR
    Immepip dihydrobromide (Standard) 164391-47-3
    Immepip (dihydrobromide) (Standard) is the analytical standard of Immepip (dihydrobromide). This product is intended for research and analytical applications. Immepip dihydrobromide is a H3 agonist. Immepip dihydrobromide can reduce cortical histamine release. Immepip dihydrobromide can be used for the research of neurological diseases.
    Immepip dihydrobromide (Standard)
  • HY-101324AR
    MK-212 monohydrochloride (Standard) 61655-58-1
    MK-212 (monohydrochloride) (Standard) is the analytical standard of MK-212 (monohydrochloride). This product is intended for research and analytical applications. MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.
    MK-212 monohydrochloride (Standard)
  • HY-101355AR
    CGP 20712 dihydrochloride (Standard) 1216905-73-5
    CGP 20712 (dihydrochloride) (Standard) is the analytical standard of CGP 20712 (dihydrochloride). This product is intended for research and analytical applications. CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors.
    CGP 20712 dihydrochloride (Standard)
  • HY-101357AR
    CP 93129 dihydrochloride (Standard) 879089-64-2
    CP 93129 (dihydrochloride) (Standard) is the analytical standard of CP 93129 (dihydrochloride). This product is intended for research and analytical applications. CP 93129 dihydrochloride is a potent 5HT1B receptor agonist. CP 93129 dihydrochloride has the potential for parkinson's disease research.
    CP 93129 dihydrochloride (Standard)
  • HY-101364AR
    CHPG sodium salt (Standard) 1303993-73-8
    CHPG (sodium salt) (Standard) is the analytical standard of CHPG (sodium salt). This product is intended for research and analytical applications. CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..
    CHPG sodium salt (Standard)
  • HY-101365AR
    RS-102221 hydrochloride (Standard) 187397-18-8
    RS-102221 (hydrochloride) (Standard) is the analytical standard of RS-102221 (hydrochloride). This product is intended for research and analytical applications. RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats.
    RS-102221 hydrochloride (Standard)
  • HY-101373AR
    Zolantidine dimaleate (Standard) 104076-39-3
    Zolantidine (dimaleate) (Standard) is the analytical standard of Zolantidine (dimaleate). This product is intended for research and analytical applications. Zolantidine dimaleate (SKF 95282 dimaleate) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine dimaleate induces antinociception.
    Zolantidine dimaleate (Standard)
  • HY-101402AR
    Cyclo(his-pro) TFA (Standard) 936749-56-3
    Cyclo(his-pro) (TFA) (Standard) is the analytical standard of Cyclo(his-pro) (TFA). This product is intended for research and analytical applications. Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.
    Cyclo(his-pro) TFA (Standard)
  • HY-101484AR
    NE-100 hydrochloride (Standard) 149409-57-4
    NE-100 (hydrochloride) (Standard) is the analytical standard of NE-100 (hydrochloride). This product is intended for research and analytical applications. NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death.
    NE-100 hydrochloride (Standard)
  • HY-101499AR
    GKT136901 hydrochloride (Standard) 1254507-01-1
    GKT136901 (hydrochloride) (Standard) is the analytical standard of GKT136901 (hydrochloride). This product is intended for research and analytical applications. GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
    GKT136901 hydrochloride (Standard)
  • HY-103234AR
    GYKI 52466 dihydrochloride (Standard) 2319722-40-0
    GYKI 52466 (dihydrochloride) (Standard) is the analytical standard of GYKI 52466 (dihydrochloride). This product is intended for research and analytical applications. GYKI 52466 dihydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 dihydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 dihydrochloride can be used in Parkinson's disease research.
    GYKI 52466 dihydrochloride (Standard)
  • HY-103565AR
    AMN082 free base (Standard) 83027-13-8
    AMN082 (free base) (Standard) is the analytical standard of AMN082 (free base). This product is intended for research and analytical applications. AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.
    AMN082 free base (Standard)
  • HY-105182AR
    Xanomeline tartrate (Standard) 152854-19-8
    Xanomeline (tartrate) (Standard) is the analytical standard of Xanomeline (tartrate). This product is intended for research and analytical applications. Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia.
    Xanomeline tartrate (Standard)
  • HY-105182S1
    Xanomeline-d3 175615-28-8
    Xanomeline-d3 (LY-246708-d3) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.
    Xanomeline-d3
  • HY-106100AR
    Roxindole hydrochloride (Standard) 108050-82-4
    Roxindole (hydrochloride) (Standard) is the analytical standard of Roxindole (hydrochloride). This product is intended for research and analytical applications. Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities.
    Roxindole hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity